ProZinc® Insulin

ProZinc® Insulin Suspension

ProZinc® Insulin Suspension  is indicated for the reduction of hyperglycemia and hyperglycemia-associated clinical signs in dogs and cats with diabetes mellitus.

Cats, Dogs

Insulin, Protamine Zinc

ProZinc®

Insulin, Long-Acting

Boehringer Ingelheim

ProZinc® 40 Units/ml Insulin 10 ml: white and cloudy/milky suspension. (NDC 00010-4499-01)

ProZinc® 40 Units/ml Insulin 20 ml: white and cloudy/milky suspension. (NDC 00010-4499-02)

Insulin, human (protamine zinc recombinant)

Protamine sulfate, zinc oxide, glycerin, dibasic heptahydrate sodium phosphate, phenol, hydrochloric acid, water

ProZinc® Insulin should be administered as directed by your veterinarian. Your veterinarian will determine the correct dose of insulin need for your pet by means of a blood glucose test. Follow your veterinarian's instructions as doses may vary over time. Use aseptic techniques when withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the stopper prior to entry with a sterile needle and syringe.

Before administering ProZinc® gently roll the vial in your hand until a uniform, milky suspension is obtained. Do not use the if clumps or visible white particles persist after gently rolling the vial. It is important that you roll the vial and not shake it. Shaking the vial may reduce the effectiveness of the insulin by breaking the insulin molecules apart.

Injections should be given subcutaneously, just under the skin. Be sure to rotate injection sites to prevent skin problems at the injection site. Pinch a fold in the skin to create a small space for the needle. Insert the needle into the center of the fold as instructed by the veterinarian. Inject the drug by pushing the plunger as far as it will go. Withdraw the needle and be careful to not stick yourself. Dispose the needle immediately in a proper sharps disposal container. 

Insulin syringes and sharps containers are sold separately.  Use only sterile needles/syringes and use each needle/syringe only once.  Injectable medications require needles and syringes.  Those items are purchased separately.  Please ask your veterinarian for a recommendation for the correct needle/syringe sizes for your pet.

Possible side effects of insulin therapy include hypoglycemia. Signs include hunger, lethargy, nervousness, vocalization, anxiety, muscle tremors or trembling, weakness, ataxia/unsteadiness. If there are signs of hypoglycemia, offer the pet some food or oral glucose. Positive response should occur within one to two minutes, then contact your veterinarian.

Other side effects may occur. If you notice anything changes in your pet, contact your veterinarian.

The following drug interactions that may occur with insulin include: Beta-adrenergic blockers, clonidine, and digoxin. Drugs that may increase hypoglycemic activity of insulin (resulting in low blood sugar) include: captopril, enalapril, alcohol, anabolic steroids, beta blockers, MAOI's, guanethidine, phenylbutazone, sulfinpyrazone, sulfonamides, tetracycline, and aspirin, or other salicyclates. Drugs that may decrease hypoglycemic activity of insulin (resulting in high blood sugar) include: epinephrine, estrogen/progesterone combinations, furosemide, glucocorticoids, isoniazide, phenothiazine derivatives, thiazide diuretics, and thyroid hormones. Serum potassium levels can fluctuate in combination with digoxin and insulin and additional monitoring may be needed. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Make sure to tell your veterinarian what other medication or supplements you are giving your pet. Dietary changes may also affect insulin requirements. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. 

This medication is indicated for the reduction of hyperglycemia and hyperglycemia-associated clinical signs in cats and dogs with diabetes mellitus.  Inform your veterinarian prior to use of this medication if your pet has low blood sugar (hypoglycemia). Do not switch from one type insulin to another unless under the direction of a veterinarian as making the switch may require an adjustment in the dose.

Keep out of reach of children. Not for human use.

Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Boehringer Ingelheim at 888-637-4251 or Vetsource customer service at 877-738-4443.

Store at 36°F to 46°F in the refrigerator, in an upright position. Do not freeze, discard if it has been frozen.

Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.